

Mattioli Engineering
A New Science in Skin Care
Distributor
Transderm DEP system

Transderm DEP (DermoElectroPoration® System) is the new Non Invasive, Stand alone powered drug-delivery system carrying Dermoelectroporation® Technology to deliver Ionic drug solution into the body for medical purposes. As result of more than five years researches, Mattioli Dermoelectroporation®, technology is consolidated to be an incredible procedure that allows the transdermal delivery of whatever substance operators want, which are otherwise not absorbed into the skin because of the typology and dimension of their own molecules.
Dermoelectroporation® infact, increases the skin’s permeability just
using some skin's water based channels opened by a particular
controlled current delivered to the patient and allowing the substances
to absobed till hypodermis and muscle membranes.
The system has been FDA approved for the “local administration of
ionic drug solutions into the body for medical purposes and can be
used as an alternative to injections”.

Medical Device Class III

Macromolecules (such as Hyaluronic
Acid) previously not transdermally
deliverable by traditional Ionthophoresis
are now successfully deliverable
due to the new Dermoelectroporation®
Technology.
Some applications
• Hyperhidrosys
• Skin Rejuvenation treatments
• Wrinkles treatments
• Pre laser treatments
• Pre and post plastic surgery sessions
• Skin Whitening treatments
• Steroids applications
• Aesthetic applications
• Replacing injections
for Mesotherapy applications
and many others
Some deliverable drugs
• Type A Botulinum Toxine
• Phosphatidylcoline
• Hyaluronic Acid
• Aminophylline
• Grow Factors
• Amino Acids
• L-Carnitine
• Lidocaine
• Heparine
• Collagen
• Vitamins
• Steroids
• Elastine
and many others
Benefit to patients
• Astonishing results
• Comfortable treatment sessions
• No irritations, burnings or inflammations
for return electrode placement
• No trauma from injections


BETTER DELIVERY FOR P.R.P.
C.G.F. AUTO-HEMOTHERAPY

As long as autohemotherapy concerns Mattioli D.E.P. transdermal devices are the most appropriate method of widespread surface delivery: effective, painless and, above all, safe thanks to the handpiece sterile disposable caps which cut down any cross contamination risk between patients. Furthermore, the Needle Free Syringe dispenser with Super Precision Liquid Dispenser loadable directly from centrifuge sample tube) due to its accuracy, allows to deliver even small solution quantities, adapting the treatment to any skin type absorption speed, avoiding product dispersion in work environment and blood-operator

SCIENTIFIC CITED BIBLIOGRAPHYSCIENTIFIC BIBLIOGRAPHY
Bianchi R. (2007). “Potentialities of autohemotherapy in chronic pathologies”, La Medicina Biologica, Luglio 2007
Rodella et al (2009). “Grow factors,DC34 positive cells, and fibrin network analysis in Concentrated Grow Factors fraction” Microscopy Research anch Tecnique.
Sohn D.S.(2009). “The use of Concentrated Grow Facrots (CGF) for sinus agumentation”. Journal of Oral Implant
Pacini S. et al. (2005).”Transdermal delivery of heparin using pulsed current inotophoresis.” Pharmaceutical Research
Pacini S. et al. (2006).”Pulsed current iontophoresis of hyaluronic acid in living rat skin.” Journal of Dermatological Science
M. Cavallini (2007). “Dermoelectroporation and botulinum toxin successfully treats Hyperidrosis.” European Aesthetic Buyers Guide

Isolifting
Medical Device Class I - FDA Registered
Isolifting™ Active cosmetic substances absorption enhancement System enhances the absorption rate of active ionic cosmetic substances applied on the skin right after the use of microdermabrasion.
Isolifting™ provides a very relaxing and pleasant massage during the treatment due to the probe vibration and promotes active ionic cosmetic substances absorption giving clients a very smooth and bright looking skin.
Isolifting™ comes out from the experience that Mattioli Engineering acquired in medical field with Dermoelectroporation® Technology, but it uses lower current pulses and limits the action to the skin surface only.
Smoother, young looking skin will be a standard with Isolifting™

What's makes Isolifting™ treatment unique?
The device comes out from the experience with Medical Dermoelectroporation® Technology
Capability to enhance the ionic active cosmetic substances absorption such as collagen, elastine etc. better than other micro-current devices on the market.
Astonishing results due to the product driven in a very homogeneos way throughout the whole area from the first sitting.
No variation of cosmetic active ionic substance PH nor substance efficacy.
Relaxing massage during pulses delivery due to a new vibration level so pleasant for the patient.
Where can I use Isolifting™ on patients?
Isolifting™ comes up with a small face applicator and it is suitable for facial treatments.
Aesthipeel®
Medical Device Class I - FDA Registered
The Aesthipeel® microdermabrader is a pure aesthetic purpose device manufactured by Mattioli Engineering .
Main applications foresee correction of skin abnormalities. Aesthipeel® performs a progressive and controlled exfoliation of the skin.Transportable, no clogging and completely disposable device, Aesthipeel® uses the Mattioli Engineering patented 45 deg. V-shaped handpiece.This specially engineered shape allows crystals to flow in a uniform and effective way, abrading the skin in a very painless way.
Aesthipeel® grants the users to work with a sterilized disposable delivery kit (i.e. bottles, corundum, tubing kit, and handpiece) in order to perform a clean and safe operations and avoiding any cross contamination risks completely. The light easy to use accessories as well as the pre set levels of vacuum power, make the Aesthipeel® to be the ideal solution for superficial and medium peeling procedure.

Ultrapeel® II plus microdermabrasion system®
Medical Device Class I - FDA Registered
Ultrapeel® II plus microdermabrasion system represents the most innovative and technologically advanced medical Micordermabrasion system suitable for dermatologists, Plastic and Cosmetic Surgeons, Medical doctors. Ultrapeel® II plus allows users to perform a huge range of treatments in a complete safe , hygienic ,sterile environment with corundum crystals saving, avoiding any cross contamination risks completely and to satisfy customer's expectations of any sort.
Saving crystals for Real.
Ultrapeel®II plus disposable delivery kit exfoliates the skin through a jet of inert corundum crystals through the patented 45 deg. V-shaped handpiece in a uniform and effective way , abrading the skin in a gentle but efficient way.No clogging and durable, Ultrapeel® II plus gives users the opportunity to save crystals by the latest crystals flow regulation feature on board. In addition to this the maximum vacuum power setting and adjustment feature makes the machine able to be configured for any type of use in complete safety for either patients and users taking care of the user and the crystal consumption.
In built compressor for critical applications.
The foot-pedal that comes up with Ultrapeel® II plus enables air compression for deeper treatments bombarding the patient's skin with sterile corundum and then vacuum it out leaving the skin free from any residua. The light easy to use accessories, the sterilization features and the power regulation make the Ultrapeel® II plus to set standards of care in the Medical field for any patient and any skin condition.
Compatible with Transderm® family of products.
Ultrapeel® have been the very first microdermabrasion systems to be cleared by the FDA on December 1996. Ultrapeel® II plus is compatiblefor the Transderm® family of products.

Ultrapeel® II microdermabrasion system®
Medical Device Class I - FDA Registered
Ultrapeel® II microdermabrasion system represents the most innovative and technologically advanced medical Micordermabrasion system suitable for either Medical and aesthetic users.
Ultrapeel® II allows users to perform a huge range of treatments in a complete safe , hygienic ,sterile environment with corundum crystals saving, avoiding any cross contamination risks completely and to satisfy customer's expectations of any sort.
Saving crystals for Real.
Ultrapeel®II disposable delivery kit exfoliates the skin through a jet of inert corundum crystals through the patented 45 deg. V-shaped handpiece in a uniform and effective way , abrading the skin in a gentle but efficient way.No clogging and durable, Ultrapeel® II gives users the opportunity to save crystals by the latest crystals flow regulation feature on board. In addition to this the maximum vacuum power setting and adjustment feature makes the machine able to be configured for any type of use in complete safety for either patients and users taking care of the user and the crystal consumption.

Ultrapeel ® Pepita Microdermabrasion Unit
Medical Device Class I - FDA Registered
Ultrapeel ® Pepita allows operators to carry out a wide range of treatments in a very safe and efficient way satisfying customer's expectations of any sort. Ultrapeel® Pepita allows users to have complete sterilized and disposable delivery kit in order to avoid any cross contamination risks completely.No Clogging and durable unit, Ultrapeel ® Pepita gently exfoliates the skin through a jet of inert corundum crystals through the patented 45 deg. V-shaped handpiece. This specially engineered shape allows crystals to flow in a uniform and efficient way , abrading the skin smoothly. Only the light easy to use accessories and the power regulation make the Ultrapeel® Pepita to set standards of care in the Aesthetic field for any patient and any skin condition. The foot-pedal enables external compressed air connections.
Ultrapeel® Pepita is already compatible with the new Ultraprobe™ Universal pre Filled , pre sterilized, disposable handpiece. Disposable accessories are the standard kit coming along with the unit. Reusable accessories are available on customer's request.
Compatible with Isoderm® family of products.
Ultrapeel® Pepita S type is compatible with Isoderm® Split Display for cosmetic substances absorption enhancment.
